The association of HHIP gene (rs1828591 and rs12504628) with Chinese Uygur patients with chronic ob?structive pulmonary disease
10.3969/j.issn.1006?5725.2017.05.005
- VernacularTitle:HHIP基因rs1828591、rs12504628与新疆维吾尔族慢性阻塞性肺疾病的相关性
- Author:
Xia REN
;
Jian GUAN
;
Zhonghong ZHANG
;
Fangjuan CHENG
;
Chengyuan MA
- Keywords:
Chronic obstructive pulmonary disease;
HHIP;
Single nucleotide polymorphism;
Rs1828591;
Rs12504628
- From:
The Journal of Practical Medicine
2017;33(5):692-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between HHIP gene with COPD patients in Xinjiang Uygur population. Methods DNA was extracted from peripheral blood samples. HHIP gene (rs1828591 and rs12504628)polymorphic loci was detected by iMLDR technique in 233 cases and 292 controls in Uygur. Results There was no significant difference in the genotype,allele frequencies distribution of 2 haplotypes of HHIP (rs1828591 and rs12504628)between the disease group and the control group(P > 0.05). There was no differ? ence in 2 haplotypes of HHIP gene between the disease group and the control group(P > 0.05). Rs1828591 and rs12504628 gene showed significance with predicted FEV1%(P < 0.05). Conclusion Rs1828591 and rs12504628 gene are related with predicted FEV1%.
