Research progress on relationship between brain metastasis from lung cancer and ex-tracellular vesicles
10.3969/j.issn.1000-8179.2017.08.080
- VernacularTitle:外泌体与肺癌脑转移瘤关系的研究进展
- Author:
Ying DANG
;
Hongjun SUN
;
Yuliang LIN
- Keywords:
brain metastases from lung cancer;
extracellular vesicle;
metastatic niche;
transfer mechanism;
target therapy
- From:
Chinese Journal of Clinical Oncology
2017;44(8):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular vesicles (EVs) are vesicles like body of phospholipid bilayer membrane, which are able to mediate the transfer of genetic material. There are receptors, proteins and nucleic acids in the body, with carrying tumor genetic material, regulating tumor microenvironment, promoting tumor angiogenesis and mediating tumor cell metastasis. At present, it is found that there is a close re-lationship between the secretion and the metastasis of lung cancer. The main aspects of the brain metastasis of the lung cancer medi-ated by the exocrine body include the regulation of the microenvironment of the brain, the destruction of the blood-brain barrier, and the regulation of tumor cell pathology. The study on the relationship between the tumor and the metastasis of lung cancer may pro-vide more molecular targets for the development, diagnosis and treatment of lung cancer.
