Coexistence of sarcoidosis and primary Sj(o)gren syndrome: a clinical analysis and literature review
10.3760/cma.j.issn.0578-1426.2017.05.014
- VernacularTitle:结节病并存原发性干燥综合征四例并文献复习
- Author:
Xinyu SONG
;
Hui HUANG
;
Yongzhe LIU
;
Yuyue ZHAO
;
Shan LI
;
Zuojun XU
- Keywords:
Sarcoidosis;
Sj(o)grens syndrome;
Diagnosis
- From:
Chinese Journal of Internal Medicine
2017;56(5):375-377
- CountryChina
- Language:Chinese
-
Abstract:
Four patients with coexistence of sarcoidosis and primary Sj(o)gren syndrome (pSS) were retrospectively analyzed.All patients were female,who were referred to our department mainly because of respiratory symptoms.Positive antinuclear antibody (ANA) was detected in 2 patients and anti-Sj(o)grens syndrome A (SSA) antibody positive in 1 patient.All patients presented specific histologic patterns of both sarcoidosis and pSS.Publications related to coexistence of these two diseases were reviewed.Forty-one patients were finally included in the analysis,among whom 37 confirmed patients were from literature search.There were 37 women and 4 men.The main clinical features presentation were xerophthalmia in 40,xerostomia in 38,hilaradenopathies in 28,interstitial lung disease in 15,respiratory symptoms in 13.The main immunologic data were positive ANA in 23,SSA antibody in 19,anti-Sj(o)grens syndrome B antibody in 10 and rheumatoid factor in 12.All patients presented specific histologic patterns of both diseases.Patients with both sarcoidosis and pSS of ten represent multisystemic involvement and positive immunologic parameters,as well as the dual expression of specific histologic characteristics.
