Association between fibroblast growth factor 21 and islet β cell function in pregnant women with different glucose tolerance status
10.3969/j.issn.1006-6187.2017.04.007
- VernacularTitle:不同糖耐量状态孕妇血清成纤维细胞生长因子21水平与胰岛β细胞功能的相关性研究
- Author:
Yakun KONG
;
Yufeng CHEN
;
Xiuqin GENG
- Keywords:
Fibroblast growth factor 21(FGF21);
Diabetes mellitus,gestational;
Islet β cell function;
Correlation
- From:
Chinese Journal of Diabetes
2017;25(4):316-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between fibroblast growth factor 21(FGF21) and islet β cell function in pregnant women with different glucose tolerance status.Methods A total of 441 pregnant women were selected in this study from our hospital.Their 50 g GCT at 24~28 gestational weeks were all positive.One week later,all the subjects were treated with 75 g OGTT,and divided into three groups according to their test results:GDM group (n=228),GIGT group (n=112) and GNGT group (n=91).Serum FGF21 level was tested by ELISA.Islet β cell function was evaluated by HOMA-IR,ISI-Matsuda,HOMA-IS,Stumvoll first,second phase secretion and ISSI.The correlation between FGF21 and islet β cell function was evaluated by Pearson correlation analysis.Results (1) BMI,0 h,1 h,2 h,3 hPG and 1 h,2 h,3 hIns were higher in GDM group and GIGT group than in GNGT group,and highest in GDM group (P<0.05 or P<0.01).SBP,DBP,0 hIns and HbA1c were higher in GDM group than in GNGT group and GIGT group(P<0.05 or P<0.01);(2)From GNGT group,GIGT group to DGM group,the levels of FGF21[(101.74±20.40) vs (137.93±25.52) vs (185.69±31.61) ng/L]and HOMA-IR[1.74(0.91,2.85) vs 2.39(1.31,4.87) vs 3.38(2.19,6.75)]were increased,while ISI-Matsuda[(58.74±15.68) vs (41.62±15.65) vs (39.73±18.98)],HOMA-IS[(157.69±88.41) vs (144.35±78.98) vs (107.30±87.23)]and ISSI[(72253.55±15167.53) vs (42313.91±7112.47) vs (30032.50±11500.24)]were decreased (P<0.05 or P<0.01).The stumvoll first,second phase secretion were lower in GDM group than in GNGT group and GIGT group(P<0.01),but there was no statistical significance between GNGT and GIGT group(P>0.05).(3)Pearson correlation analysis showed that FGF21 was positively correlated with HOMA-IR(r=0.255,P=0.030) and was negatively correlated with ISI-Matsuda,HOMA-β,Stumvoll first,second phase secretion and ISSI(r=-0.289,-0.256,-0.224,-0.230,-0.277,P=0.019,0.037,0.045,0.040,0.023).Conclusion Along with the worsening of glucose metabolic damage,the FGF21 level is increased gradually.FGF21 is related to islet β cell function,and may enroll in the occurrence and development of GDM.
