Expressions of TXNIP,STAMP2 and GATA3 and the changes of serum oxidative stress indexes in diabetic patients with breast cancer
10.3969/j.issn.1006-6187.2017.04.013
- VernacularTitle:糖尿病伴乳腺癌患者硫氧还蛋白结合蛋白、前列腺跨膜上皮抗原2、转录因子家族中成员GATA3的表达及血清氧化应激指标的变化
- Author:
Jing TANG
;
Li YANG
- Keywords:
Breast cancer;
Diabetes mellitus;
Thioredoxin-interactingprotein(TXNIP);
Six-transmembrane protein of prostate 2(STAMP2);
Transcription factor(GATA3);
Oxidative stress(OS)
- From:
Chinese Journal of Diabetes
2017;25(4):344-350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the expressions of TXNIP,STAMP2 and GATA3 in diabetes patients with breast cancer and to determine the changes of oxidative stress indexes before and after surgery.Methods The expression levels of TXNIP,STAMP2 and GATA3 mRNA in cancer tissues and adjacent normal tissues were measured in 45 diabetes patients with breast cancer.The levels of serum oxidative stress indexes including MDA,MPO,SOD and TAC were detected and compared before and after surgery.Results The expressions of TXNIP,STAMP2 and GATA3 mRNA and their protein levels in cancer tissues were lower than those in adjacent normal tissues (P<0.05).The positive expression rate of the three indexes were 60%,66.7% and 73.3%,higher than that of TXNIP protein with 2.2% in the adjacent normal tissues(P<0.05).The TXNIP,STAMP2 and GATA3 protein positive rate of breast cancer tissue were related to differentiation,lymph node metastasis and clinical grades (P<0.05).Serum MDA and MPO levels increased first and then decreased.SOD and TAC showed a trend of decrease first and then increase.The turning point is 6 d after surgery.Conclusion TXNIP,STAMP2,GATA3 and serum oxidative stress indicators may be the indicators for diagnosis and treatment of breast cancer in diabetes patients.
