Levels of plasma VEGF,TPS and TuM2-PK before and after interventional therapy in lung cancer
10.3969/j.issn.1673-4130.2017.07.018
- VernacularTitle:血浆VEGF、TPS、TuM2-PK水平在肺癌介入治疗前后的表达及意义
- Author:
Chao ZHANG
- Keywords:
lung cancer;
vascular endothelial growth factor;
tissue polypeptide specificity antigen;
tumor type M2 pyruvate kinase
- From:
International Journal of Laboratory Medicine
2017;38(7):916-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of vascular endothelial growth factor (VEGF),tissue polypeptide specificity antigen (TPS) and tumor type M2 pyruvate kinase (TuM2-PK) before and after interventional therapy in lung cancer (LC).Methods Sixty cases of LC treated by interventional treatment in our hospital from January 2013 to January 2015 were analyzed.The levels of VEGF,TPS and TuM2-PK on preoperative 1 d,postoperative 1,3,7,14,28 d were detected by enzyme-linked immunosorbent assay(ELISA).The change of VEGF,TPS and TuM2-PK levels in the patients with different treatment outcomes was observed.Contemporaneous 40 individuals undergoing healthy physical examination served as the healthy control group.Results The levels of VEGF,TPS,TuM2-PK on preoperative 1d,postoperative 3,7,14,28 d had statistical differences between the observation group and control group (P<0.05,P<0.01).Compared with pre-treatment,the levels of VEGF,TPS and TuM2-PK in partial remission patients were significantly improved,which in the patients with stable and progressive condition,the levels of VEGF,TPS and TuM2-PK were significantly increased (P<0.05).Conclusion The levels of VEGF,TPS and TuM2-PK are significantly elevated before and after interventional treatment in LC patients,moreover the worse the therapeutic efficacy,the higher the levels of VEGF,TPS and TuM2-PK,which can be used as the detection indexes of LC interventional treatment.
