Comparison of several common detection indexes of cell senescence
10.3867/j.issn.1000-3002.2017.04.009
- VernacularTitle:几种常见细胞衰老检测指标的比较
- Author:
Yiyuan ZHANG
;
Fang XIAO
- Keywords:
cell senescence;
detection;
index
- From:
Chinese Journal of Pharmacology and Toxicology
2017;31(4):352-357
- CountryChina
- Language:Chinese
-
Abstract:
Cell senescence is a state of irreversible growth arrest, which can be triggered by a variety of different cellular stress. Currently, the detection indexes involved in the study of cell senes?cence include senescence-associated β-galactosidase, telomeres and telomerase, senescence-associ?ated heterochromatin foci, senescence-associated secretory phenotype, reactive oxygen species, and tumor suppressor genes p53 and p16. These indexes are widely used in the study of cell senescence, each with its own characteristics or advantages. This review summarizes several common cell senes?cence indexes and compares their accuracy, credibility, specificity, and potential applications.
