Impact on NO, iNOS, IL-1 and IL-6 levels of isosorbide mononitrate in lung tissue of spontaneously hypertensive rats (SHR)
10.3969/j.issn.1006-5725.2017.04.012
- VernacularTitle:单硝酸异山梨酯对SHR肺组织NO、iNOS、IL-1及IL-6水平的影响
- Author:
Wenfei ZHAO
;
Hongyun LI
;
Bing BAI
- Keywords:
Isosorbide mononitrate;
SHR;
Lung tissue;
NO;
iNOS;
IL-1;
IL-6
- From:
The Journal of Practical Medicine
2017;33(4):547-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of isosorbide mononitrate on the levels of NO,iNOS,IL-1 and IL-6 in lung tissue of spontaneously hypertensive rats (SHR).Methods Fourteen-week-old Wistar and SHR male rats were randomly divided into the W0,W1,S0 and S1 group,with 10 rats ineach group.Rats in the W0 and S0 group were fed with the normal saline and the ordinary food,rats in the W1 and S1 group were fed with isosorbide mononitrate and the ordinary food.Twelve weeks later,levels of NO,iNOS,IL-1 and IL6 in rat lung tissue were detected.Results Compared with the W0 group,levels of NO,iNOS,IL-1 and IL6 were significantly increased in the W1 groups (P ＜ 0.05,respectively).Compared with the SO group,levels of NO,iNOS,IL-1 and IL6 were significantly increased in the S1 group (P ＜ 0.05,respectively).In the W1 and S1 group,levels of iNOS and NO were positively correlated with IL-1 and IL-6.Conclusion 1.Isosorbide mononitrate may lead to increases of NO,iNOS,IL-1 and IL6 in lung tissue of Wistar rats,which indicates the presence of chronic inflammation.2.Longterm feeding of isosorbide mononitrate may lead to increases of inflammatory factors in SHR rats,contributing to the inflammatory state in rats.
