Multicenter clinical study of the predictive value of neutrophil gelatinase-associated lipocalin for contrast-induced acute kidney injury after emergency percutaneous coronary intervention in patients with relative normal renal function
10.3969/j.issn.1006-5725.2017.04.014
- VernacularTitle:床边快速检测NGAL对急诊冠脉介入后造影剂所致急性肾损伤预测的多中心研究
- Author:
Kun WANG
;
Ning TAN
;
Yong LIU
;
Jiyan CHEN
;
Nianjin XIE
;
Danqin YU
;
Ling XUE
;
Jianfeng YE
;
Yan LIANG
- Keywords:
Neutrophil gelatinase associated lipocalin;
Acute myocardial infarction;
Percutaneous coronary intervention;
Contrast-induced acute kidney injury
- From:
The Journal of Practical Medicine
2017;33(4):554-557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of neutrophil gelatinase associated lipocalin (NGAL) for contrast-induced acute kidney injury (CI-AKI) after emergency percutaneous coronary interventions (PCI) in patients with relative normal renal function.Methods A total of 73 patients with relative normal renal function undergoing PCI were enrolled in this prospective multicenter clinical study.Serum NGAL was measured by point-of-care test.Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of NGAL for CI-AKI.Results CI-AKI occurred in 5 patients (6.85％).The concentration of NGAL was higher in the CI-AKI group than in the non-CI-AKI group.ROC curve indicated that the area under the receiver operating characteristic was 0.755,0.761 and 0.809,respectively.Conclusions Serum NGAL at baseline,4 h and 8 h after procedure are served as a good biomarker for early diagnosis of CI-AKI after PCI.Therefore,NGAL might become an early and quick marker for CI-AKI in the future.
