Study on the diagnostic and treatment value of serum B-type natriuretic peptide levels for the chronic heart failure and its correlation with cardiac function classification
10.3760/cma.j.issn.1008-6706.2017.08.008
- VernacularTitle:血清B型脑钠肽水平对慢性心力衰竭诊治价值及其与心功能分级的相关性研究
- Author:
Weiqun ZHU
;
Xiaoming ZHANG
;
Hong TAO
;
Tao SUN
;
Pingping ZHANG
- Keywords:
Heart Failure;
Natriuretic Peptide,Brain;
Heart Function Tests
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(8):1152-1155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic and treatment value of serum B-type natriuretic peptide (BNP) levels for the chronic heart failure and its correlation with cardiac function classification.Methods 155 patients with heart failure were selected as treatment group.According to cardiac function,grade Ⅱ in 48 cases,grade Ⅲ in 56 cases,grade Ⅳ in 51 cases.122 healthy people during the same period were selected as the control group.Retrospectively detected serum BNP levels of the subjects,and the BNP levels of the treatment group were detected before and after treatment,and its correlation with heart function was analyzed.Results The serum BNP level of the treatmentgroup was (738.67 ± 61.32) pg/mL,which was higher than (22.36 ± 21.89) pg/mL of the control group,the difference was statistically significant (t =19.38,P ＜ 0.05).The serum BNP level of the treatment group after treatment was (329.58 ± 90.74) pg/mL,which was lower than (738.67 ± 161.32) pg/mL of the control group,the difference was statistically significant(t =19.38,P ＜ 0.05).The serum BNP levels of grade Ⅱ,grade Ⅲ and grade Ⅳ patients after treatment compared with pre-treatment,the differences were statistically significant (t =13.65,15.18,17.39,all P ＜ 0.05),from pre-treatment to pro-treatment,the serum BNP levels were gradually increased with increased grade,the differences were statistically significant (t =10.61,21.33,11.06,16.40,all P ＜ 0.05).Conclusion The serun BNP level of chronic heart failure patients significantly increases,and it increases with the increase of cardiac function classification,and shows correlation.As the objective indicators of chronic heart failure,it has better clinical diagnosis value and treatment and prognostic significance.
