Subtype distribution analysis of human papillomavirus in women in Jinhua People's Hospital
10.3760/cma.j.issn.1008-6706.2017.08.026
- VernacularTitle:浙江省金华市人民医院妇科门诊女性感染宫颈上皮细胞人乳头瘤病毒亚型分布特征分析
- Author:
Weidong XU
;
Yue LI
;
Xianlin TENG
;
Chen ZHENG
;
Xinping ZHANG
;
Feifei WU
;
Chihui LI
- Keywords:
Uterine Cervical Neoplasms;
Human papillomavirus 16;
Human papillomavirus 18;
Genotype
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(8):1225-1228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the infection and subtype distribution of human papillomavirus (HPV) in cervical epithelial cell line in the People's Hospital of Jinhua.Methods 26 kinds of HPV genotypes were detected by gene chip,and the infection states among all subtypes were analyzed.Results A total of 25 genotypes of HPV were identified in 984 female patients,with the positive rate of 36.89％.The top three common high-risk HPV,ranging from high to low according to positive rate were HPV-16,58 and 52.The positive rates of high-risk HPV,low-risk HPV and multiple infection rate were 25.91％,5.69％ and 5.28％,respectively.The positive rates of the age groups of 21-30 years,＞ 30-40 years and ＞ 40 years were 42.33 ％,35.23％ and 35.94％,respectively.There were significant differences among the three age groups in the detection rate of high-risk HPV,low-risk type and multiple infection rate(x2 =71.58,P ＜ 0.05).Conclusion HPV 16,58 and 52 are the main high-risk genotypes of the 984 women in our hospital.The genotyping of HPV has important significance in the prevention,treatment and etiology of cervical cancer,as well as in the study of HPV vaccine.
