Research advances in therapy of dry age-related macular degeneration
10.13389/j.cnki.rao.2017.0097
- VernacularTitle:干性年龄相关性黄斑变性治疗的研究进展
- Author:
Yanzhi ZHANG
;
Hui PENG
- Keywords:
dry age-related macular degeneration;
oxidative stress;
lipofuscin;
drusen;
ciliary neurotrophic factor;
nanoceria;
human monoclonal antibody;
photoreceptor transplantation
- From:
Recent Advances in Ophthalmology
2017;37(4):379-383
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(AMD) is the major cause of irreversible damage to vision in over 60 years old.Its incidence is increasing with age.Dry AMD is one of the most common types,causing the loss of vision is very slow.At the late stage,the geographic atrophy will be found,in which central vision is severely lost.It is widely believed that chronic inflammantion injury,oxidative stress injury,lipofuscin,drusen and choroid ischemia are the major pathogenesis.Now,the treatment is major aiming to the pathogenesis.But some new therapies such as crocetin,curcumin,ciliary neurotrophic factor,nanoceria,human monoclonal antibody,photoreceptor and stem cell transplantation have some efficiency to dry AMD.This article reviews the research advances in therapy of dry AMD.
