Effect of ligustrazine on cardiac inflammation in rats with type 2 diabetes mellitus
10.3969/j.issn.1000-4718.2017.04.028
- VernacularTitle:川芎嗪通过抗炎作用减轻2型糖尿病大鼠心肌病变
- Author:
Xinyuan ZHAO
;
Kui XU
;
Cairong LI
;
Juan LI
;
Fengping LIN
;
Caiyan LI
;
Jiazhong SUN
;
Xiao CHEN
- Keywords:
Ligustrazine;
Myocardial inflammation;
Type 2 diabetes mellitus
- From:
Chinese Journal of Pathophysiology
2017;33(4):744-748
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of ligustrazine on the cardiacmyocyte lesion in rats with type 2 diabetes mellitus.METHODS: Male Wistar rats were injected with STZ via tail vein under high-glucose and high-fat feeding for 4 weeks to establish the animal model of type 2 diabetes mellitus.Ligustrazine at different doses was used to treat the diabetic rats.The body weight, blood glucose and the morphology of heart tissues were observed.The myocardial levels of IL-1β, IL-6 and TNF-α were detected by ELISA, and the protein expression of IKKβ and NF-κB in the myocardium was determined by Westeren blotting.RESULTS: Ligustrazine at high dose alleviated the body weight reduction and blood glucose elevation cause by diabetes, and reduced pro-inflammatory factors IL-1β, TNF-α and IL-6.Moreover, the protein expression of IKKβ and NF-κB was significant decreased by ligustrazine.CONCLUSION: Ligustrazine inhibits the myocardial inflammation caused by diabetes through anti-inflammatory pathway.
