Research advance on function and molecular mechanism of takeda G protein-coupled receptor 5 in obstructive jaundice
10.3760/cma.j.issn.1673-9752.2017.04.023
- VernacularTitle:G蛋白偶联受体5在梗阻性黄疸中的作用及分子机制研究进展
- Author:
Yong TAN
;
Guixin ZHANG
;
Wei BI
- Keywords:
Obstructive jaundice;
Takeda G protein-coupled receptor 5;
Bile acid
- From:
Chinese Journal of Digestive Surgery
2017;16(4):437-442
- CountryChina
- Language:Chinese
-
Abstract:
Bile acid can not only emulsify fat and facilitate the absorption of fat soluble substances,but also it is an important signaling molecules that plays an important physiological role by activating specific bile acid receptors.Takeda G proteincoupled receptor 5 (TGRS) is a membrane receptor of the bile acid,it can activate G-protein effectors and promote the expression of the second messenger and activate a variety of signal transduction pathways to exert physiological functions.The obstructive jaundice bile acid can cause a series of pathophysiological reactions through activating TGR5,which plays a significant role in the obstructive jaundice.In this article,the latest researches about the function and molecular mechanism of TGR5 in obstructive jaundice were reviewed in order to provide a new idea for exploring the new method and strategy to cure the disease.
