The analysis of bone metabolism in hospitalized patients with Graves disease and the changes after 131I therapy
10.3969/j.issn.1672-8467.2017.02.010
- VernacularTitle:住院Graves病患者骨代谢状况与131I治疗后转归分析
- Author:
Wenjie MA
;
Chaoyang LV
;
Yao ZHANG
;
Guiping XU
;
Shunmei HE
;
Mengjuan XUE
;
Jian GAO
;
Mingxiang YU
- Keywords:
Graves disease;
bone metabolism;
131I therapy
- From:
Fudan University Journal of Medical Sciences
2017;44(2):186-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the bone metabolism in hospitalized patients with Graves disease and the changes after 131I therapy.Methods The differences of bone metabolism were analyzed between 315 patients with Graves disease and 300 normal controls in a case-control study.The changes in bone turnover markers and BMD levels before and one year after 131I therapy were observed in 60 patients.Results Compared to normal control,bone turnover markers were markly higher and BMD levels were lower in patients with Graves disease.The level of thyroid hormones were positively related to bone turnover markers,while negatively related to total hip BMD (Z-score).But there was no linear relationship with lumbarand femoral neck BMD (Z-score).After one year of 131I therapy,bone turnover markers were markly lower than that before treatment,while BMD levels were partly higher than that before treatment.Conclusions In Graves disease patients,bone turnover markers were generally increased,while BMD levels decreased compared with normal people.After 131I therapy,along with the improvement of thyrotoxicosis,the high bone turnover rate can be suppressed,and BMD can partly recover.
