Expression, functions and regulation of PKM2 in tumor cells
10.3969/j.issn.1672-8467.2017.02.016
- VernacularTitle:肿瘤中M2型丙酮酸激酶的表达、功能及调节
- Author:
Mengkun SHI
;
Yu SHI
;
Qun WANG
- Keywords:
M2 type of pyruvate kinase;
tumor metabolism;
transcrptional level
- From:
Fudan University Journal of Medical Sciences
2017;44(2):217-223
- CountryChina
- Language:Chinese
-
Abstract:
M2 type of pyruvate kinase (PKM2) is one of the most important regulatory molecules in glycolysis,which at high level is a major feature of tumor cells.Besides,PKM2 also regulates gene transcription and cell cycle,promoting the formation,invasion and migration of tumors.Meanwhile,PKM2 can beregulated by many transcription factors,oncogene proteins,miRNA and intermediate metabolites.Extensive studies indicated that PKM2 plays an important role in the developmental tumor.In view of the significance of PKM2 in tumor cells,it holds promise for diagnosis and treatment benefits.
