Research progress of H19 gene in the field of tumor research
10.3969/j.issn.1672-8467.2017.02.017
- VernacularTitle:H19基因在肿瘤研究领域的研究进展
- Author:
Xiaodong WANG
- Keywords:
gene imprinting;
tumor;
lncRNAH19;
miR675
- From:
Fudan University Journal of Medical Sciences
2017;44(2):224-230
- CountryChina
- Language:Chinese
-
Abstract:
Since human imprinted genes in 11P15.5 was found,it had been proved that various human physiological abnormality associated with it.As one of the first identified imprinted non-coding RNA genes,more attention is paid to lncRNA H19 by many scholars not only because it's linked with Beckwith-Wiedemann syndrome (BWS) and Russell syndrome (SRS),but also H19 gene is the only imprinted gene belonging to long non-coding RNA related with a variety of tumors which can also produce microRNA675 and lncRNA 91H coming from H19 gene antisense-coding.This paper will review possible mechanisms of H19 gene in tumorigenesis process and its research status in Cancer therapy from four aspects:imprinting feature,single nucleotide polymorphisms,lncRNA character and its possible action signal axis in cancer.
