Research progress on the changes of subchondral bone in osteoarthritis and its molecular mechanisms
10.3969/j.issn.1672-8467.2017.02.018
- VernacularTitle:骨关节炎软骨下骨的变化及其分子机制的研究进展
- Author:
Bingxuan HUA
- Keywords:
osteoarthritis;
subchondral bone;
OPG/RANKL/RANK system;
TGFβ;
estrogen;
estrogen receptors;
lipid metabolism
- From:
Fudan University Journal of Medical Sciences
2017;44(2):231-237
- CountryChina
- Language:Chinese
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Abstract:
Osteoarthritis (OA) is one of the most common chronic osteoarthritic diseases,which can involve the whole joint.Subchondral bone is an important part of the joint and has a close relationship to the development of OA.The changes and mechanisms of subchondral bone in OA are complex and remain disputes.In this review,we will discuss the advances of the molecular mechanisms of subchondral bone in OA,which include the pathological changes and the roles of the OPG/RANKL/RANK system,transforming growth factor β (TGFβ),estrogen-estrogen receptors and lipid metabolism in OA.
