Role of nicorandil in protecting myocardium of very old patients with non-ST segment elevation myocardial infarction

VernacularTitle:尼可地尔对高龄非ST段抬高型急性心肌梗死患者的心肌保护作用
Author: Ping DING ; Hong CHEN ; Haiyan ZHANG
Keywords: nicorandil; myocardial infarction; troponin Ⅰ; electrocardiography
From: Chinese Journal of Geriatric Heart Brain and Vessel Diseases 2017;19(4):374-376
CountryChina
Language:Chinese
Abstract: Objective To study the role of nicorandil in protecting myocardium of very old patients with non-ST segment elevation myocardial infarction.Methods Ninety-six very old patients with non-ST segment elevation myocardial infarction admitted to our hospital from March 2012 to July 2016 were randomly divided into experimental group (n=48) and control group (n=48).After 4 weeks of comprehensive treatment,the patients in experimental group were given oral nicorandil (5 mg,3 times a day).The serum cTnI level was measured in 2 groups before treatment and on days 1,3,7 and 10 after treatment.The ECG of 2 groups was observed before and after treatment.Results The serum cTnI level was significantly lower in experimental group than in control group on days 3,7 and 10 after treatment (3.24±4.31 μg/L vs 10.47±t4.72 μg/L,P＜0.05;0.53±0.31 μg/L vs 2.50±1.45 μg/L,P＜0.01;0.09±0.07 μg/L vs O.41±0.26 μg/L,P＜0.01).The ECG was significantly better in experimental group than in control group after treatment (P＜0.05).Conclution Oral nicorandil can protect the myocardium of very old patients with non-ST segment elevation myocardial infarction.