Dexmedetomidine improves function of lung oxygenation in patients with moderate chronic obstructive pulmonary disease underwent lung cancer surgery
10.11817/j.issn.1672-7347.2017.03.006
- VernacularTitle:右美托咪定改善合并中度慢性阻塞性肺疾病肺癌手术患者的肺氧合功能
- Author:
Jiru ZHANG
;
Nan DONG
;
Hongdi QIAN
;
Weifeng YU
- Keywords:
dexmedetomidine;
one-lung ventilation;
oxygenation index;
lung mechanics
- From:
Journal of Central South University(Medical Sciences)
2017;42(3):271-276
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine whether dexmedetomidine (Dex) improves oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease (COPD) during lung cancer surgery.Methods:Fifty-six patients with moderate COPD were randomly allocated to a control group and a Dex group (n=28 each).In the Dex group,dexmedetomidine was given as an initial loading dose at 1.0 μg/kg lasting for 10 min followed by a maintenance dose at 0.5 μg/(kg-h) during OLV while the control group was administered an equal volume of 0.9％ saline accordingly.Results:Patients in the Dex group had a significantly higher oxygenation index (P＜0.05) and higher dynamic lung compliance at Dex-30 and Dex-60 (P＜0.05) compared with those in the control group.In the Dex group,oxygenation index in the postoperative period was significantly higher (P=0.025) and postoperative complications were lower than those in the control group.Conclusion:Dex administration may provide dinically relevant benefits by improving oxygenation index and lung mechanics,and reducing postoperative pulmonary complications in patients with moderate COPD underwent lung cancer surgery.
