Value of 1H-MRS on SCA3/MJD diagnosis and clinical course
10.11817/j.issn.1672-7347.2017.03.009
- VernacularTitle:1H-MRS对SCA3/MJD的诊断价值及与临床病程的关系
- Author:
Wu XING
;
Xinxin LIAO
;
Tingting GUAN
;
Fangfang XIE
;
Lu SHEN
;
Weihua LIAO
;
Xiaoyi WANG
- Keywords:
spinocerebellar ataxia 3/Machado-Joseph disease;
proton magnetic resonance spectroscopy;
international cooperative ataxia rating scale;
scale for the assessment and rating of ataxia
- From:
Journal of Central South University(Medical Sciences)
2017;42(3):291-297
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of proton magnetic resonance spectroscopy (1H-MRS) on the diagnosis of SCA3/MJD,and to calculate the correlation between 1H-MRS ratio and the clinical score.Methods:Sixteen patients with SCA3/MJD and 19 healthy volunteers were scanned with 1H-MRS.The data of N-acetyl aspartate,creatine,choline-containing compounds,myoinositol,NAA/Cr,Cho/Cr,and mI/Cr ratio were collected,which were grouped for comparative study.The onset patients with SCA3/MJD were evaluated with the International Cooperative Ataxia Rating Scale and Scale for the Assessment and Rating of Ataxia,the correlation between NAA/Cr,Cho/Cr or mI/Cr ratio and the clinical score was calculated.Results:The NAA/Cr in the pons and cerebellar dentate nucleus from the onset patients with SCA3/MJD was significantly reduced compared to that in the normal control group.The NAA/Cr in the cerebellar dentate nucleus of onset patients with SCA3/MJD was obviously correlated with ICARS.Conclusion:SCA3/MJD lesions are mainly located in the cerebellum and brainstem,where gray and white mater are also involved.The cerebellar dentate nucleus may be the earliest involved area.There is a correlation between the ICARS and the cerebellar lesion degree.The ICARS reflects the severity of clinical manifestations.1H-MRS is useful in the diagnosis of SCA3/MJD.
