Correlation among concentrations of high sensitive C reactive protein, uric acid, brain natriuretic peptide and coronary heart disease
10.3969/j.issn.1008-0074.2017.02.07
- VernacularTitle:超敏C反应蛋白、尿酸、脑钠肽与冠心病的相关性
- Author:
Jun ZHAO
;
Lijun ZHANG
- Keywords:
Coronary disease;
C reactive protein;
Uric acid;
Natriuretic peptide;
brain
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore correlation among concentrations of high sensitive C reactive protein (hsCRP), uric acid (UA), brain natriuretic peptide (BNP) and coronary heart disease (CHD).Methods: A total of 120 CHD patients treated in our department were enrolled as CHD group, and they were divided into single vessel coronary disease group (single-vessel group, n=51) and multi-vessel coronary disease group (multi-vessel group, n=69).Meanwhile, another 40 healthy subjects were randomly selected from our physical examination center as healthy control group.Serum concentrations of hsCRP, BNP and UA were measured in all groups, and compared with pairwise comparisons.Results: Compared with healthy control group, there were significant rise in serum concentrations of hsCRP[(3.95±2.24) mg/L vs.(19.78±5.15) mg/L], BNP[(70.57±19.47) pg/ml vs.(196.17±54.84) pg/ml], UA[(184.51±79.47) μmol/L vs.(407.17±96.84) μmol/L]in CHD group, and those of multi-vessel group were significantly higher than those of single-vessel group, P<0.05 or <0.01;Spearman rank correlation analysis indicated that serum UA concentration was significant positively correlated with hsCRP and BNP concentrations (r=0.551, 0.398, P<0.05 both), Gensini score was significant positively correlated with serum concentrations of hsCRP, BNP, UA (r=0.478, 0.552, 0.741, P<0.05 all), Sullivan score was significant positively correlated with serum concentrations of hsCRP, BNP, UA (r=0.503, 0.674, 0.892, P<0.05 or <0.01) in CHD patients.Conclusion: Serum concentrations of hsCRP, BNP, UA are closely related to occurrence and development of CHD.These three indexes can be used as screening indexes for CHD, and the effect of combined detection may be better.
