Correlation between plasma oxidized low density lipoprotein and vascular endothelial injury degree in patients with coronary heart disease
10.3969/j.issn.1008-0074.2017.02.14
- VernacularTitle:冠心病患者血浆氧化低密度脂蛋白与血管内皮损伤程度的相关性
- Author:
Jinliang ZHANG
;
Wenjuan WANG
;
Bo BAI
;
Kun MA
- Keywords:
Coronary disease;
Endothelium;
vascular;
Lipoproteins;
LDL
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(2):167-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore correlation between plasma oxidized low density lipoprotein (ox-LDL) and endothelial injury degree in patients with coronary heart disease (CHD).Methods: A total of 80 CHD patients were enrolled as CHD group, and 21 healthy subjects were selected as healthy control group.Plasma ox-LDL, circulatory endothelial cell count (CEC), nitric oxide (NO) levels were measured and compared between two groups, and their correlation was analyzed.Results: Compared with healthy control group, there were significant rise in plasma ox-LDL level[(350±173) μg/L vs.(687±169) μg/L]and CEC[(2.5±0.5) ×106个/L vs.(9.0±1.7) ×106个/L], and significant reduction in NO level[(77.4±21.1) μmol/L vs.(52.3±16.6) μmol/L]in CHD group, P<0.05 or <0.01.Spearman correlation analysis indicated that ox-LDL was significant positively correlated with CEC (r=0.793, P=0.019), and ox-LDL, CEC were significant negatively correlated with NO level (r=-0.782,-0.952, P=0.013, 0.021).Conclusion:There are significant positively correlation between ox-LDL and circulatory endothelial cell count(Vascular endothelial injury degree) in CHD patients, therefore, its treatment should focus on anti-inflammatory and endothelial cell function protection.
