New research progress of neuregulin-1
10.3969/j.issn.1008-0074.2017.02.32
- VernacularTitle:神经调节蛋白-1的研究新进展
- Author:
Wenjing LIU
;
Chao CHANG
- Keywords:
Neuregulin-1;
Receptor protein-tyrosine kinases;
Stem cells
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(2):228-230
- CountryChina
- Language:Chinese
-
Abstract:
Neuregulin-1 (NRG-1) can bind with its tyrosine kinase receptor via paracrine and autocrine, activate downstream pathways and perform a series of biological reactions, and reduce pressure load and improve heart function through inhibiting sympathetic nerve excitement.Recent study identified that NRG-1 can induce pluripotent stem cell differentiation;clinical trials proved that recombinant human NRG-1 can reduce level of N terminal pro brain natriuretic peptide, rehospitalization rate and onset times of heart failure.The present article made a review on research progress of NRG-1 in cardiovascular field.
