Relationship between HRCT expression and airway inflammation in patients with asthma airway remodeling

VernacularTitle:哮喘气道重塑患者HRCT的表现与气道炎症程度的关系研究
Author: Xiaoyu WU ; Liutao HE ; Huachun CHEN
Keywords: high resolution spiral CT; airway basement membrane thickness; airway inflammation
From: Chinese Journal of Biochemical Pharmaceutics 2017;37(4):407-409
CountryChina
Language:Chinese
Abstract: Objective To study the assessment of airway inflammation in asthma patients with airway remodeling by high resolution spiral CT(HRCT).Methods Retrospective analysis on 60 cases of chronicity-persistent period asthma patients with induced sputum IL-4 test,airway mucosa biopsy,HRCT scan; while 20 patients only used HRCT scan as control group.To compare the difference of sputum IL-4,HRCT test of airway wall thickness(WT),wall area(WA)and airway wall relative area(WA％)in different degrees of asthma paitents.Results WA,WA％and WT were significantly increased in different degrees of asthma patients when compared to control group(P<0.05),there were significant difference among each group(P<0.05).WA％and WT were positively correlated with induced sputum IL-4.Conclusion HRCT can effectively evaluate the airway inflammation in airway remodeling of asthma patients,which can be used to evaluate the severity of asthma,treatment effect and follow-up observation.