Effect of intensive atorvastatin therapy on B7-H4 in peripheral blood monocytes of patients with unstable angina undergoing percutaneous coronary intervention
10.3969/j.issn.1006-5725.2017.06.034
- VernacularTitle:强化剂量阿托伐他汀对不稳定型心绞痛患者经皮冠脉介入术围手术期B7-H4的影响
- Author:
Jing LV
;
Ge XU
;
Chen HUANG
;
Min LEI
;
Jingjing ZHANG
;
Bingning MA
- Keywords:
Unstable angina;
B7-H4;
Atorvastatin;
PCI
- From:
The Journal of Practical Medicine
2017;33(6):975-978
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the intensive atorvastatin therapy on B7-H4 in peripheral blood monocytes of patients with unstable angina PCI undergoing percutaneous coronary intervention. Methods 80 patients with unstable angina were randomized to pretreatment with intensive dose (80 mg/day ,n = 40) and conventional dose(20 mg/day,n=40)of atorvastatin. Peripheral blood were subsequently obtained prior to PCI,and 18 ~ 24 h after PCI. Peripheral blood serum level of IL-4,IL-10 and IFN-γ were quantified using enzyme-linked immunosorbent assays. Fluorescence-based quantitative real-time PCR was used to measure levels of periph-eral blood monocytes B7-H4 mRNA. Results Levels of IL-10 ,sB7-H4 and B7-H4 mRNA increased in patients of both groups after PCI. The increase in intensive dose group is more significant (P < 0.05). IL-4 and IFN-γ decreased in patients of both groups after PCI. The decrease in intensive dose group is more significant (P <0.05). Conclusion Intensive dose atorvastatin treatment improve post-PCI immune inflammation in patients with unstable angina,possibly by promoting the expression of B7-H4 in peripheral blood monocytes.
