Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer.
- Author:
Sokbom KANG
1
;
Woong JU
;
Jae Weon KIM
;
Noh Hyun PARK
;
Yong Sang SONG
;
Seung Cheol KIM
;
Sang Yoon PARK
;
Soon Beom KANG
;
Hyo Pyo LEE
Author Information
1. Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi-do 410-769, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
DNA repair;
drug resistance, neoplasm;
ERCC1 protein, human;
ovarian neoplasms;
polymorphism, single nucleotide
- MeSH:
Survival Analysis;
Polymorphism, Single Nucleotide/*genetics;
Ovarian Neoplasms/drug therapy/*genetics/pathology;
Multivariate Analysis;
Middle Aged;
Linkage Disequilibrium;
Humans;
Genotype;
Gene Frequency;
Female;
Epithelial Cells/pathology;
Endonucleases/*genetics;
Drug Resistance, Neoplasm/genetics;
Disease Progression;
DNA-Binding Proteins/*genetics;
DNA Repair;
Codon/genetics;
Cisplatin/*therapeutic use;
Antineoplastic Agents/therapeutic use;
Aged;
Adult;
Adolescent
- From:Experimental & Molecular Medicine
2006;38(3):320-324
- CountryRepublic of Korea
- Language:English
-
Abstract:
ERCC1 is a DNA repair gene and has been associated with resistance to DNA damaging agents. In this study we hypothesized that a polymorphism of ERCC1 Asn118Asn (C->T) might affect the platinum-resistance of epithelial ovarian cancer patients to platinum-taxane chemotherapy administered postoperatively. Using the SNapShot assay, we assessed this polymorphism in ERCC1 in 60 ovarian cancer patients. Platinum-resistance was defined as progression on platinum-based chemotherapy or recurrence within 6 months of completing therapy. Although not significant, platinum-resistance was less frequently observed in patients with the C/T+T/T genotype (P=0.064). Multivariate analysis showed that the C/T+T/T genotypes constituted an independent predictive factor of reduced risk of platinum-resistance in ovarian cancer (odds ratio 0.17, 95% confidence interval 0.04-0.74, P=0.018, Fisher's exact test). No significant correlation was observed between overall survival and the ERCC1 polymorphism. Our results suggest that genotyping of the ERCC1 polymorphism Asn118Asn may be useful for predicting the platinum-resistance of epithelial ovarian cancer patients. However, these findings require prospective confirmation.
