Influence of glycosylated hemoglobin on major adverse cardiovascular events in patients with diabetes mellitus complicated coronary heart disease after PCI
10.3969/j.issn.1008-0074.2017.02.03
- VernacularTitle:糖化血红蛋白对糖尿病伴冠心病患者PCI后主要心血管不良事件的影响
- Author:
Xintao ZHOU
;
Libing ZHAO
;
Xinwen MIN
;
Jiao CHEN
;
Mingjian LANG
- Keywords:
Hemoglobin A;
glycosylated;
Diabetes mellitus;
Coronary disease
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study influence of glycosylated hemoglobin A1c (HbA1c) on major adverse cardiovascular events (MACE) in patients with diabetes mellitus (DM) complicated coronary heart disease (CHD) after percutaneous coronary intervention (PCI).Methods: A total of 100 DM+CHD patients after PCI were selected from our hospital.According to HbA1c level, they were divided into HbA1c<6.5% group (n=48) and HbA1c≥6.5% group (n=52).Levels of C reactive protein (CRP), tumor necrosis factor α (TNF-α), erythrocyte sedimentation rate (ESR) and interleukin (IL)-6 before PCI, incidence rate of MACE on six and 24 months after PCI were compared between two groups.Results: Compared with HbA1c<6.5% group before PCI, there were significant rise in serum levels of CRP[(18.5±6.2) mg/L vs.(25.8±4.2) mg/L]and TNF-α[(32.4±12.3) ng/L vs.(48.3±11.8) ng/L]in HbA1c≥6.5% group, P<0.01 both.On six months after PCI, incidence rate of myocardial infarction in HbA1c≥6.5% group was significantly higher than that of HbA1c<6.5% group (9.62% vs.0, P=0.028);24 months after PCI, compared with HbA1c<6.5% group, there were significant rise in incidence rates of myocardial infarction (2.08% vs.15.38%) and diseased vessel restenosis (12.50% vs.32.69%) in HbA1c≥6.5% group (P<0.05 all).Conclusion: In DM+CHD patients after PCI, those with lower HbA1c level possess better prognosis.
