Comparison of therapeutic effects of clopidogrel and loading dose ticagrelor on aged patients with ST elevation myocardial infarction
10.3969/j.issn.1008-0074.2017.02.20
- VernacularTitle:氯吡格雷和负荷量替格瑞洛在老年ST段抬高型心肌梗死患者中的疗效对比
- Author:
Shikang ZHENG
;
Hui REN
;
Juan SHU
- Keywords:
Myocardial infarction;
Aged;
Angioplasty;
balloon;
coronary
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2017;26(2):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare therapeutic effects of clopidogrel and loading dose ticagrelor on aged patients with ST elevation myocardial infarction (STEMI).Methods: A total of 160 aged STEMI patients undergoing emergency percutaneous coronary intervention (PCI) were selected.According to random number table, they were randomly and equally divided into clopidogrel group (received loading dose aspirin and clopidogrel therapy) and ticagrelor group (received loading dose aspirin and ticagrelor therapy).Coronary TIMI flow grade, incidence rate of no-reflow after PCI, and incidence of cardiac adverse events and bleeding events in one month after PCI were compared between two groups.Results: Compared with clopidogrel group after PCI, there was significant rise in percentage of coronary TIMI flow grade 3 (71.25% vs.90.00%), and significant reduction in incidence rate of no-reflow (28.75% vs.10.00%) in ticagrelor group,P<0.05 all.Compared with clopidogrel group on one month after PCI, there were significant reductions in incidence rates of cardiogenic death (13.75% vs.3.75%), in-stent thrombosis (6.25% vs.0) and recurrent myocardial infarction (10.00% vs.1.25%), but significant rise in incidence rate of dyspnea (3.75% vs.12.50%) in ticagrelor group, P<0.05 all.There was no significant difference in incidence of bleeding events between two groups, P>0.05 all.Conclusion: Loading dose ticagrelor can effectively improve coronary blood flow, reduce no-reflow and its safety is good in aged patients with ST elevation myocardial infarction, which is worth extending.
