Comparison of the clinical characteristics of ovarian lymphoma and ovarian cancer with bulk lymph node involvement
10.19401/j.cnki.1007-3639.2017.04.007
- VernacularTitle:卵巢淋巴瘤和以淋巴结转移为主的卵巢癌临床特征比较
- Author:
Feifei GAO
;
Lei GUO
;
Kai XUE
;
Weiqi SHENG
;
Wei WANG
;
Mujie LI
;
Zhong ZHENG
;
Ziting LI
- Keywords:
Ovarian lymphoma;
Ovarian cancer;
Clinic characteristics;
CA125;
Lactate dehydrogenase
- From:
China Oncology
2017;27(4):281-286
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: Ovarian lymphoma (OL) is usually misdiagnosed as ovarian cancer with bulk lymph node invasion (OC-BLN), and vice versa. Therefore, to distinguish these two types of disease, we compared their clinical characteristics in this study. Methods: This study retrospectively reviewed 14 OL and 14 OC-BLN patients from Fudan University Shanghai Cancer Center and Shanghai Eighth People's Hospital. The clinical char-acteristics, image and laboratory examination data were compared. Results: There was no significant difference in age, symptom, fever, weight loss and volume of ascitic fluid between the two groups. Comparing with OC-BLN, OL patients have larger tumor in ovaries [(13.04±5.94) cm vs (7.78±6.38) cm, P=0.033], and higher percentage of solid ovarian tumor (85.71% vs 28.5%, P=0.006). Lactate dehydrogenase(LDH)/CA125 was higher in OL (7.66±8.03) than OC-BLN (0.31±0.27, P=0.009). Using LDH/CA125 to diagnose OL, area under the curve (AUC) was 0.952. When the threshold value was set at 1, the sensitivity and specificity was 91.7% and 100%, respectively. Conclusion: OL and OC-BLN are easily to be misdiagnosed. OL has larger and more solid tumor than OC-BLN. LDH/CA125 can help to distinguish these two diseases and guide clinical decision making.
