Roles of inflammasome in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2017.02.013
- VernacularTitle:炎性小体在脑缺血中的作用
- Author:
Ling TONG
;
Zhiqiang SU
- Keywords:
Brain Ischemia;
Inflammasomes;
Inflammation;
Reactive Oxygen Species;
Interleukin-1 β;
NLR Proteins;
Toll-Like Receptors;
Signal Transduction;
Caspase 1;
Cell Death;
Apoptosis
- From:
International Journal of Cerebrovascular Diseases
2017;25(2):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Innate immunity plays an important role in inflammatory injury after cerebral ischemia,and inflammasome is considered to be a key factor.Inflammasome is a macromolecular protein complex,can recognize pathogen-associated molecular patterns and damage-associated molecular patterns,and mediate immune inflammatory responses.Studies have shown that cerebral ischemia can induce the acute activation of the NLRP1 and NLRP3 inflammasomes.This article reviews the structure,activation and regulation of inflammasome,and the roles of inflammasome in cerebral ischemia.
