Preparation and in vitro Release Study of Diphenidol Hydrochloride Double-layer Osmotic Pump Tablets
10.6039/j.issn.1001-0408.2017.13.27
- VernacularTitle:盐酸地芬尼多双层渗透泵片的制备及体外释放研究
- Author:
Lanqiong ZHU
;
Hui LIU
;
Shiqin LIAO
;
Ting DUAN
- Keywords:
Diphenidol hydrochloride;
Double-layer osmotic pump tablets;
Preparation;
Formulation;
Cumulative release
- From:
China Pharmacy
2017;28(13):1823-1826
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Diphenidol hydrochloride double-layer osmotic pump tablets,and study its in vitro release characteristics. METHODS:Double-layer compressing technique and film coating technology were conducted to prepare Diphenidol hydrochloride double-layer osmotic pump tablets. The in vitro releases of it,Difenidol hydrochloride tablets in market,self-made Difenidol hydrochloride single-layer osmotic pump tablets were compared. RESULTS:The formulation was as follow as diphenidol hydrochloride 75 mg,sodium chloride 10 mg,low-molecular-weight polyoxyethylene 15 mg and right amounts of 5% PVP K30 ethanol solution. Booster layer was high-molecular-weight polyoxyethylene 60 mg,sodium chloride 20 mg,PVP K306 mg,right amounts of magnesium stearate. 12 h cumulative release(Q)of prepared double-layer osmotic pump tablets reached 80%,and the release was in line with zero-order kinetic equation. Q15 min of Difenidol hydrochloride tablets had reached 90%;Q12 h of Difenidol hy-drochloride single-layer osmotic pump tablets was only 51.14%. CONCLUSIONS:The prepared Difenidol hydrochloride dou-ble-layer osmotic pump tablets have sustained release effect,with more complete drug release within 12 h than single-layer one.
