Optimization of Ultrafine Pulverization Technology in Chaige Tuire Powder
10.6039/j.issn.1001-0408.2017.13.31
- VernacularTitle:柴葛退热散超微粉碎工艺优化
- Author:
Liangjing LIU
;
Jun QI
;
Yingcheng ZHU
;
Jing YU
;
Qiang ZHANG
- Keywords:
Chaige tuire powder;
Ultrafine powder;
Pulverization technology;
Orthogonal test;
HPLC;
Puerarin;
Glycyrrhi-zin;
Baicalin;
Content determination;
Microcharacteristics
- From:
China Pharmacy
2017;28(13):1837-1841
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the ultrafine pulverization technology in Chaige tuire powder;to compare the content and microcharacteristics between ultrafine powder and ordinary powder. METHODS:Using contents of 3 active ingredients(puera-rin,glycyrrhizin and baicalin)and powder d(0.5)as main indexes,bulk density,angle of repose and microcharacteristic as refer-ence indexes,orthogonal test was designed to optimize the initial particle size,moisture and pulverized frequency in ultrafine pul-verization technology. Contents of 3 active ingredients of ultrafine powder and ordinary powder(over 65/80 mesh sieve)and obser-vation results of calcium oxalate crystal under microscope were compared. RESULTS:The optimized technology was as follow as over 65 mesh sieve,moisture of 2.5%preliminary powder in 60 Hz of frequency for pulverization. In verification test,d(0.5)aver-age value of 3 ultrafine powder samples was 31.5 μm(RSD=0.45%,n=3);contents of puerarin,glycyrrhizin and baicalin were 0.232 mg/g(RSD=1.31%,n=3),0.212 mg/g(RSD=1.62%,n=3),8.962 mg/g(RSD=0.89%,n=3),respectively,which were increased about 30%-40% than in ordinary powder(0.158,0.15669,6.140 mg/g). There were no or little bundles of calci-um oxalate crystal that is common in ordinary powder. CONCLUSIONS:Optimized ultrafine pulverization technology is stable and feasible;contents of 3 active ingredients in Chaige tuire ultrafine powder are higher and calcium oxalate crystal are litter than ordi-nary powder,which possibly reduces the adverse reactions in clinical application.
