Effects of epalrestat combined with methylcobalamin on quality of life of patients with diabetic peripheral neuropathy
10.3760/cma.j.issn.1008-6706.2017.11.007
- VernacularTitle:依帕司他联合甲钴胺对糖尿病周围神经病变患者生存质量的影响
- Author:
Xianglan LIU
- Keywords:
Diabetes mellitus;
Peripheral nervous system diseases;
Epalrestat;
Mecobalamin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(11):1623-1626
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of epalrestat combined with methylcobalamin on quality of life of patients with diabetic peripheral neuropathy.Methods 124 patients with diabetic peripheral neuropathy were randomly divided into the control group and the observation group according to the random number table, each group had 62 cases.The two groups were treated on the basis of the effective control of blood glucose and medication to control peripheral neuropathy, the control group used mecobalamin, the observation group used epalrestat combined with methylcobalamin, the two groups were treated continuously for 60 days.The effects of two main physiological changes, clinical efficacy and quality of life were observed.Results The total effective rate of the observation group was 95.2%,which was higher than 80.6% of the control group, the difference was statistically significant(x2=3.072,P<0.05).The fasting plasma glucose(FPG),postprandial 2 h plasma glucose(2 h PPG), glycosylated hemoglobin(HbA1c) were improved compared with before treatment, the differences were statistically significant(all P<0.05),which of the observation group improved significantly better than the control group, the differences were statistically significant(all P<0.05).The evaluation indicators of body pain(BP),social function(SF), role physiological(RP) and mental health(MH) had statistically significant differences compared with the control group (t=16.964,44.583,30.204,44.114,all P<0.05).Conclusion Using epalrestat combined with methylcobalamin tablets in the treatment of patients with diabetic peripheral neuropathy can significantly improve blood glucose levels, clinical symptoms, the quality of life of patients and it has great clinical significance.
