Microglia mediated inflammatory signaling pathways after ischemic stroke
10.3760/cma.j.issn.1673-4165.2017.02.014
- VernacularTitle:缺血性卒中后小胶质细胞介导的炎性信号通路
- Author:
Zhi MA
;
Yi ZHU
;
Juan BU
- Keywords:
Stroke;
Brain Ischemia;
Microglia;
Inflammation;
Signal Transduction;
Inflammasomes;
Receptors,Cytokine;
Toll-Like Receptors;
Receptor,Notch
- From:
International Journal of Cerebrovascular Diseases
2017;25(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Microglia is the most important immune cell in the central nervous system.It plays a key role in mediating the immune response in the central nervous system.Sterile inflammation is the key factor in the pathophysiological process following ischemic stroke.Microglia is activated and induces a series of inflammatory signals through binding of injuring related ligands to their corresponding receptors.This article introduces the activation of microglia and inflammatory response after ischemic stroke from Toll-like receptors,inflammasome,cytokine receptors,Notch signaling and other signaling pathways.
