Investigation of the Compatible Stability of Cefpirome Sulfate with Ornidazole
10.6039/j.issn.1001-0408.2017.13.16
- VernacularTitle:硫酸头孢匹罗与奥硝唑配伍稳定性考察
- Author:
Hong LI
;
Qiong ZOU
;
Zheng PING
;
Li WEI
;
Yumei CHANG
;
Jizhang YANG
- Keywords:
Cefpirome sulfate;
Ornidazole;
Compatibility;
Stability;
Appearance;
pH value;
Content
- From:
China Pharmacy
2017;28(13):1784-1786
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the compatible stability of cefpirome sulfate with ornidazole. METHODS:At room temperature [(20±1)℃],the appearances(color,clarity,sedimentation and gas)and pH changes of the mixtures by Cefpirome sulfate for injection with Ornidazole for injection in 0.9% Sodium chloride injection and 5% Glucose injection after 0,1,2,4,6 h were observed. RP-HPLC was adopted to determine its content changes. RESULTS:No significant change was noted for the mix-ture in appearance within 6 h,pH value ranged in 3.359-3.588;compared with the beginning(0 h),the contents of cefpirome sul-fate and ornidazole ranged in 100.2%-100.3%,99.9%-100.4% in 0.9% Sodium chloride injection at each time point,as well as 99.7%-99.9%,99.4%-99.6%in 5%Glucose injection. CONCLUSIONS:At room temperature,cefpirome sulfate mixed with orni-dazole show stable appearance,pH value and content in 0.9%Sodium chloride injection and 5%Glucose injection within 6 h.
