Expression of serum ADAM33 in patients with different severity of asthma and the relation to airway chronic inflammation
10.16571/j.cnki.1008-8199.2017.05.015
- VernacularTitle:解整合素-金属蛋白酶33在不同严重程度哮喘患者血清中的表达水平及其与气道慢性炎症的关系
- Author:
Liping FANG
;
Min CHEN
;
Fang ZHANG
;
Xin SU
;
Pengpeng ZHANG
;
Xiaofeng XIN
;
Yi SHI
- Keywords:
A disintegrin and metalloproteinase33;
Severity of asthma;
Chronic inflammation
- From:
Journal of Medical Postgraduates
2017;30(5):521-524
- CountryChina
- Language:Chinese
-
Abstract:
Objective A distintegrin and metalloproteinase 33 (ADAM33) is one of the asthma susceptibility gene, which is closely related to the pathogenesis of asthma and airway hyperreactivity.The aim of this study was to evaluate the expression of serum ADAM33 in patients with different severity of asthma and the relation to airway chronic inflammation through clinical trials.MethodsPatients diagnosed as mild-to-moderate asthma (n=54), severe asthma (n=35) and healthy controls (n=30) were recruited from May 2015 to May 2016.The serum IgE, ADAM33, IL-4 and IL-13 1evels and Eosinophil (EOS) in peripheral blood were detected, and the correlation analysis was performed Results The serum levels of ADAM33 in mild-to-moderate asthma group, severe asthma group and healthy control group were 23.8±6.21pg/mL,64.8±12.8pg/mL and 18.3±4.49pg/mL, respectively.The ADAM33 levels in mild-to-moderate asthma group and severe asthma group were higher than those in control group (P<0.05).The ADAM33 levels in severe asthma group were higher than those in mild to moderate asthma group.(P<0.05).The correlation analysis showed that ADAM33 had positive correlation with IL-4 and IL-13(r=0.79 and r=0.81), but no correlation with EOS and IgE(r=0.54 and r=0.46).Conclusion The expression of serum ADAM33 was up-regulated in asthmatic patients along with the severity of asthma.ADAM33 was positively correlated with serum IL-4 and IL-13, implying that the expression of ADAM33 may be regulated by Th2 type cytokines.
