Postoperative epileptic recurrence in patients with glioma-related epilepsy: Clinical characteristics and risk factors
10.16571/j.cnki.1008-8199.2017.04.014
- VernacularTitle:胶质瘤相关性癫痫患者术后痫性再发的临床特征及影响因素
- Author:
Zhuo YANG
;
Xinjun WANG
;
Qiao SHAN
;
Peidong LI
;
Yuehui WU
;
Jingwei XIE
;
Zhen WANG
- Keywords:
Glioma-related epilepsy;
Onset characteristics;
Cox regression model;
Seizure-associated factors
- From:
Journal of Medical Postgraduates
2017;30(4):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective Few studies are reported on the clinical characteristics of glioma-related epilepsy (GRE).Postoperative recurrence of epilepsy in some patients seriously affects their recovery.We aimed to explore the duration, frequency and type of the epileptic seizure as well as possible factors for postoperative recurrence of epilepsy.Methods We recorded the frequency and duration of epileptic seizures, analyzed the recurrence-related factors using the Cox regression model, and investigated the risk factors of recurrent epilepsy.Results The postoperative recurrence of epilepsy was found in 24 (26.97%) of the 89 cases, which, compared with the 65 non-recurrence cases, had a significantly longer seizure duration (7[3-10] vs 5[2-9] min, P<0.05) and higher onset frequency (6.5[4-9] vs 5[3-9] times/mo, P<0.05) preoperatively.After surgery, the 24 recurrence cases showed a remarkably reduced seizure duration (1[0.5-2.0] min, P<0.05) and onset frequency (1.5[1-3] times/mo, P<0.05).The main risk factors for epileptic recurrence included the level of the glioma-involved site (HR=6.728, 95% CI: 2.994-15.116), peritumoral edema (>2 cm) (HR=2.867, 95% CI: 1.210-6.795), brain wave type (HR=2.501, 95% CI: 1.058-5.914), and preoperative frequency of epileptic seizure (>6 times/mo) (HR=5.100, 95% CI: 2.437-10.677).Conclusion Postoperative recurrence of epilepsy is associated with the clinical pathological parameters, and the changes of the frequency and duration of epileptic seizures before and after surgery may provide some new theoretical reference for the treatment and prognosis of the disease.
