Preparation and Evaluation of Kaempferol Molecularly Imprinted Monolithic Column with MolecularSimulation-Living Radical Polymerization
10.11895/j.issn.0253-3820.160320
- VernacularTitle:分子模拟-活性自由基聚合法制备山奈酚分子印迹整体柱及其性能评价
- Author:
Turson MAMAT
;
Emin RISALAT
;
Jelil MAHMUTJAN
;
Dawut GULBAHAR
;
Ganghui CHU
;
Xuebo YIN
- Keywords:
Kaempferol;
Molecularly imprinted polymer;
Monolithic column;
High performance liquid chromatography;
Molecular simulation
- From:
Chinese Journal of Analytical Chemistry
2017;45(5):741-746
- CountryChina
- Language:Chinese
-
Abstract:
Molecular simulation was used to study the interaction between template molecule and functional monomer to shorten the optimization time for the functional monomer and the ratio of functional monomer and template molecule.Kaempferol molecularly imprinted polymerization (MIP) monolithic column was therefore synthesized by reversible addition-fragmentation chain-transfer (RAFT) polymerization with dibenzyltrithiocarbonate (DBTTC) and ethyleneglycoldim ethacrylate (EDMA) as RAFT and cross-linking agent, respectively, whereas methacrylic acid (MAA) was the optimal functional monomer with the molar ratio of kaempferol/MAA of 1∶4 from molecular simulation results.The results indicate that molecular simulation is useful to simplify the experimental procedure, and DBTTC as RAFT agent can provide more adjustable and better MIP monolithic column.
