Research advances of absent in melanoma 2 in the development of cancer

VernacularTitle:黑色素瘤缺乏因子2在肿瘤发生发展中的研究进展
Author: Zhi ZHANG
Keywords: Absent in melanoma 2; Innate immunity; Inflammasome; Tumor
From: Journal of Medical Postgraduates 2017;30(5):542-545
CountryChina
Language:Chinese
Abstract: Absent in melanoma 2 (AIM2) is a cytoplasmic protein, which can identify and combine with the cytoplasmic dsDNA to activate caspase-1, and promote the maturation and release of IL-1β and IL-18, or induce pyroptosis.AIM2 belongs to the innate immune system and is the first line of defense to protect the body against the invasion of alien microbes.After identifying the pathogenic microorganisms, the activation of the host signal caused the reaction, which started microorganisms.The activation of the host signal caused the reaction, which started the innate immune and acquired immune response.Research also suggests that AIM2 plays an important role in the occurrence and development of tumor, which was abnormally expressed in many malignant tumors such as prostatic cancer, colorectal cancer, breast cancer, nasopharyngeal carcinoma, oral squamous cell carcinoma, non small cell lung cancer, and AIM2 plays different roles in the progression of different tumor.This article will summarize the research progress of AIM2 in innate immunity and tumor development.