The activation of inflammasome and non-viral liver disease

VernacularTitle:炎症小体活化与非病毒性肝病的研究进展
Author: Chenkai HUANG ; Cong HE
Keywords: Liver disease; Inflammasome; Interleukin; Caspase
From: Journal of Medical Postgraduates 2017;30(5):546-550
CountryChina
Language:Chinese
Abstract: Inflammasomes are multiprotein complexes that can sense danger signals from damaged cells or pathogens and assemble to mediate the activation of caspase-1, which proteolytically activates the proinflammatory cytokines IL-1β and IL-18.Uniquely, inflammasome activation needs two steps to induce inflammation.Its activation has been studied in human and different experimental liver diseases and demonstrated to have effects on hepatocyte damage, immune cell activation and amplification of liver inflammation.In this review, inflammasome and their functions in variant liver diseases (especially ALD, NASH, ischemia-reperfusion liver injury) will be discussed in detail.These findings could help us deepen our understanding about these diseases, and provide new clues to the therapy of them in clinical practice.