Interpretation of tacrolimus guidelines for individualized medication
10.16571/j.cnki.1008-8199.2017.04.002
- VernacularTitle:他克莫司个体化用药指南解读
- Author:
Chen CHEN
;
Yanjie ZHANG
;
Xiaolu HE
;
Xuejiao LIU
;
Tingting LIU
;
Xiaohui HUANG
;
Yingying TAO
;
Huijie YUE
;
Xiaoyi CHEN
;
Meng WEI
;
Jianzhong RUI
;
Guohua ZHOU
- Keywords:
Tacrolimus;
Therapeutic drug monitoring;
Polymorphism;
Dosing recommendations
- From:
Journal of Medical Postgraduates
2017;30(4):342-347
- CountryChina
- Language:Chinese
-
Abstract:
Tacrolimus exhibits varied individual pharmacokinetic and a narrow therapeutic window, resulting in difficulties in personalized medication.In order to improve the safety of tacrolimus in clinical application and its efficiency and rationality in clinical practice, many countries and regions in the world have issued a number of guidelines for tacrolimus application.However, these guidelines generally aim at particular disease and race, and have certain limitation.In this article, the guidelines were explicated and analyzed in detail.Moreover, an individual tacrolimus medication recommendation for Chinese population was summarized based on the latest research of tacrolimus pharmacogenomics and therapeutic drug monitoring so as to provide assistance for the rational use of tacrolimus.
