Expression of miR-124 and its relationship with E-cadherin and androgen receptor in triple-negative breast cancer
10.11904/j.issn.1002-3070.2017.02.001
- VernacularTitle:三阴性乳腺癌中miRNA-124表达与E-钙黏蛋白及雄激素受体的关系
- Author:
Dabei TANG
;
Yan JIN
;
Zhenqin GONG
;
Zhong CHU
;
Zhongru CAO
;
Qingyuan ZHANG
- Keywords:
Triple-negative breast cancer;
miR-124;
E-cadherin;
Androgen receptor
- From:
Practical Oncology Journal
2017;31(2):97-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study was to explore the expression of miRNA-124(miR-124)and its correlation with E-cadherin and androgen receptor(AR)in triple-negative breast cancer(TNBC).Methods The expression of miR-124 was detected by RT-PCR in TNBC tissues and adjacent normal breast tissues.The expression of E-cadherin and AR in TNBC was detected by immunohistochemistry.Results The expression of miR-124 in TNBC tissues was significantly correlated with histological grade and the expression of E-cadherin(P<0.05),and the expression of miR-124 in TNBC tissues was significantly lower than that in adjacent normal breast tissues.No correlation was found between miR-124 and AR in TNBC tissues(P>0.05).Conclusion In TNBC,miR-124 may play an anti-tumor effect by modulating the expression of E-cadherin.
