Expression of transcription factors Sp1 and Survivin in breast cancer and their correlation
10.11904/j.issn.1002-3070.2017.02.003
- VernacularTitle:转录因子Sp1和存活素在乳腺癌中的表达及相关性研究
- Author:
Xiaoyu SHI
;
Jing ZHANG
;
Wei MENG
;
Junfeng ZHAO
- Keywords:
Sp1;
Survivin;
Breast carcinoma;
Prognosis
- From:
Practical Oncology Journal
2017;31(2):107-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study was to investigate the expression and clinical significance of transcription factors Sp1 and Survivin in breast cancer and to further analyze their correlation.Methods Seventy cases of breast cancer patients were diagnosed as breast cancer from June 2013 to June 2015.The expression of Sp1 and Survivin in 70 cases of breast cancer and 20 cases of adjacent normal tissues were detected by immunohistochemical staining.The relationship was detected between the protein expression and the clinicopathological parameters of breast cancer.Results The positive rates of Sp1 and Survivin in breast cancer were 71.43% and 78.57%,respectively.The positive rates of Sp1 and Survivin were 30% and 10% in adjacent normal breast tissues.They showed a significant difference(P<0.05).In breast cancer tissues,there were no differences in the lymph node metastasis,TNM stage and vessel infiltration(P>0.05).There were also no differences in the age,tumor size and histological grade of patients with breast cancer(P>0.05).In breast cancer tissues,there was a significant positive correlation between Sp1 and Survivin expression(r=0.517,P<0.01).Conclusion The transcription factors Sp1 and Survivin are closely related to the pathogenesis of breast cancer,which may serve as an adjunctive index for the diagnosis of breast cancer.It has certain guiding value for clinical diagnosis,treatment and prognosis of breast cancer.
