Expression of PSMD10 and Ki67 in epithelial ovarian carcinoma and its clinicopathological significance
10.11904/j.issn.1002-3070.2017.02.004
- VernacularTitle:上皮性卵巢肿瘤组织中PSMD10、Ki67的表达及其临床病理意义
- Author:
Ge YU
;
Jianing SUN
;
Xiaoling FENG
- Keywords:
Ovarian cancer;
PSMD10;
Ki67;
Immunohistochemistry
- From:
Practical Oncology Journal
2017;31(2):112-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective The objective of this study was to investigate the expression of PSMD10 and Ki67 in epithelial ovarian tumors and its clinicopathological significance.Methods Immunohistochemical method was used to detect the expression of PSMD10 and Ki67 in 21 cases of ovarian benign tumor,31 cases of ovarian borderline tumor and 156 cases of ovarian cancer.Results The positive expression rate of PSMD10 and Ki67 in ovarian cancer was significantly higher than those of ovarian borderline and benign tumor(P<0.05).The positive expression rate of PSMD10 in ovarian cancer tissues was not different from others groups(P>0.05).There was significant different the positive expression rate of PSMD10 from clinical stage,pathological grade and residual tumor diameter(P<0.05).There was a positive correlation between the expression of PSMD10 and Ki67 in ovarian cancer(P<0.01).Conclusion PSMD10 and Ki67 play an important synergistic role in the carcinogenesis and progression of epithelial ovarian cancer.It can be used as an important index to judge the degree of malignancy and progression of ovarian cancer.Joint testing PSMD10 and Ki67 are used to guide the clinical diagnosis.
