The relevancebetween genetic polymorphismof NR3C1andaggressive behavior in Yunnan Han population
10.13618/j.issn.1001-5728.2017.02.008
- VernacularTitle:云南汉族NR3C1基因多态性与暴力攻击行为相关性
- Author:
Aiting NIE
;
Liping HU
;
Yang CHEN
;
Hua FU
;
Xiufeng ZHANG
;
Min RAO
;
Wenkai SONG
;
Shengjie NIE
- Keywords:
forensic biology;
NR3C1;
polymorphism;
aggressive behavior
- From:
Chinese Journal of Forensic Medicine
2017;32(2):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the polymorphisms of NR3C1 gene and aggressive behavior in Yunnan Han population.Methods Five SNPs of the NR3C1 gene (rs6190,rs6191,rs6198,rs41423247 and rs56149945) were genotyped in 194 unrelated prisoners who committed violent-crimes and 301 healthy controls using improved Multiplex-ligase-detection reaction(iMLDR) method,and the data were statistically analyzed with the SPSS19.0soflware and PHASE2.1platform.Results Single locus analysis showed that the allelic distribution of rs6191and rs41423247did not show significant differencesbetween the control groupand the aggressive-behavior group as well as the robbery sub-group and intentional injury sub-group.However,significant difference was foundin the rs41423247 genotype distribution betweencontrol groupand robbery sub-group (p=0.048).In addition,there were no significant differences for the four haplotypes between the control group,the attack group,the robbery subgroup and the intentional injury subgroup.Conclusion These findings indicate that rs41423247 polymorphism of the NR3C1gene might play a role in susceptibility to aggressive behavior and rs6191 polymorphismmay not be correlated withaggressive behavior.
