Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis.
10.4167/jbv.2015.45.3.272
- Author:
Soo Young CHOI
1
;
Sung Jae SHIN
Author Information
1. Department of Microbiology, Institute of Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. sjshin@yuhs.ac
- Publication Type:Review
- Keywords:
Tuberculosis;
Mycobacterium tuberculosis;
Immunomodulation;
PE/PPE protein
- MeSH:
Clinical Coding;
Genome;
Host-Pathogen Interactions;
Humans;
Immunomodulation;
Mycobacterium tuberculosis*;
Mycobacterium*;
Tuberculosis;
Vaccines
- From:Journal of Bacteriology and Virology
2015;45(3):272-281
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.
