Effects and mechanism of penehyclidine hydrochloride combined with ulinastatin onpostoperative cognitive function in patients undergoing thoracic surgery
10.3969/j.issn.1671-8348.2017.12.006
- VernacularTitle:盐酸戊乙奎醚复合乌司他丁对行开胸术患者术后认知功能的影响及机制研究
- Author:
Min WANG
;
Bo GAO
;
Yue MA
;
Yang ZHANG
;
Bo MA
;
Xiangrong CHAI
;
Zheng LIU
- Keywords:
penehyclidine hydrochloride;
ulinastatin;
thoracotomy;
inflammation;
postoperative cognitive function
- From:
Chongqing Medicine
2017;46(12):1602-1605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of penehyclidine hydrochloride combined with ulinastatin on postoperative cognitive function in the patients undergoing thoracic surgery.Methods One hundred and twenty patients undergoing lung cancer thoracotomic radical resection were randomly divided into hydrochloride penehyclidine composite ulinastatin group(HU group),hydrochloride penehyclidine group(H group),ulinastatin group(U group)and control group(C group).The arterial blood was collected for detecting OI,TNF-α,IL-6 and IL-8.The serum levels of S-100β and NSE were detected.The MMSE scores were evaluated.Results Compared with the H group and U group,the levels of TNF-α at T3-4 in the HU group were decreased,and the levels of IL-6 and IL-8 at T2-4 were decreased,while OI was increased(P＜0.05).Compared with the H group and U group,the serum levels of S-100β and NSE at T5-8 in the HU group were decreased(P＜0.05);compared with the H group and U group,the MMSE scores at T6-7 in the HU group were increased(P＜0.05).Conclusion Penehyclidine hydrochloride combined with ulinastatin could reduce the inflammation reaction during one lung ventilation in thoractomy and improves the postoperative cognitive function.
