Study on clinical relationships between gene polymorphism of vitamin D receptor and adiponectin with susceptibility of non-alcohol fatty liver disease
10.3969/j.issn.1671-8348.2017.12.007
- VernacularTitle:维生素D受体和脂联素基因多态性和非酒精性脂肪肝易感性临床关系研究
- Author:
Zhoutao HE
;
Canxia XU
;
Xiangyang HAN
;
Yiyao CHEN
;
Yi CHEN
- Keywords:
receptors;
calcitriol;
adiponectin;
gene polymorphism;
non-alcohol fatty liver disease;
susceptibility
- From:
Chongqing Medicine
2017;46(12):1606-1609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss and analyze the clinical relationships between the gene polymorphism of vitamin D receptor and adiponectin with the susceptibility of non-alcohol fatty liver disease(NAFLD).Methods One hundred and two cases of NAFLD were selected as the observation group,and other 100 healthy volunteers were selected as the control group.The gene polymorphism of vitamin D receptor and adiponectin in the two groups was detected,then the genotype distribution and allele frequencies of vitamin D receptor and adiponectin were compared between the two groups,then their relationship with the susceptibility of NAFLD was analyzed.Results The genotype distribution situation of vitamin D receptor BsmI site,adiponectin 45 and 276 sites had statistically significant difference between the observation group and control group(P＜0.05).The B allele frequency of BsmI site of vitamin D receptor in the observation group was far lower than that in the control group,and the allele frequencies of 45-T and 276-G of vitamin D receptor in the former were far higher than those in the latter,and the differences between the two groups were statistically significant(P＜0.05).The multivariate unconditional Logistic regression analysis showed that vitamin D receptor:bb genotype,adiponectin 45 locus:TT genotype and ALT,TG,complicating hypertension history and HOMA-IR all were the independent risk factors in NAFLD patients.Conclusion The genotype distribution of different sites of vitamin D receptor and adiponectin has obvious abnormality in the patients with NAFLD,and both are closely related with the NAFLD susceptibility.
