Clinical study of ulinastatin combined with CRRT in the treatment of multiple organ dysfunction syndrome
10.3969/j.issn.1671-8348.2017.11.011
- VernacularTitle:乌司他丁持续静脉泵入联合CRRT治疗MODS的临床研究
- Author:
Hongshan KANG
;
Yan BAI
;
Yajing LIU
;
Jing WANG
;
Shuhong LIU
;
Huiqing WANG
;
Zhen MA
;
Fang DING
;
Zhaobo CUI
- Keywords:
ulinastatin;
continuous renal replacement therapy;
multiple organ failure
- From:
Chongqing Medicine
2017;46(11):1478-1481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical curative effect of ulinastatin combined with CRRT in the treatment of multiple organ dysfunction syndrome(MODS).Methods Sixty eight patients with MODS who were admitted to ICU from July 2013 to July 2015 were randomly divided into three groups:control group,CRRT group,combined group;Patients' APACHE Ⅱ,SOFA scores level of inflammatory markers were recorded before treatment and after treatment of 72 hours and 7 days.The mortality of the three groups in ICU were compared.Results After 72 hours and a week of treatment,the level of IL-10,IL-6,TNF-α,WBC、PCT、CRP in CRRT group and combined group were significantly better than that of control group(P＜0.05),and combined group were significantly better than that of CRRT group.Compared with the control group,the oxygen index,lactic acid,ALT significantly im proved in CRRT group and combined group were better than control group,after 72 hours and a week of treatment(P＜0.05),and the cornbined group was the most obvious.After a week of treatment,the mortality rate of CRRT group and combined group was significantly better than the control group (P＜0.05),while there was no statistical differences between CRRT group and combined group(P＞0.05).Conclusion Ulinastatin combined with CRRT is an effective method for the treatment of MODS.
